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Position: Research Fellow
Institution: University College London
Department: Neurodegenerative Disease
Location: London, United Kingdom
Duties: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two neurodegenerative disorders for which no cure is currently available. A GGGGCC (G4C2) repeat expansion in C9orf72 is the most frequent genetic cause.The repeats undergo an unconventional translation mechanism, termed repeat-associated non-ATG translation, whereby they mediate their own translation into proteins, without the need for an ATG start codon. Five different dipeptide repeat proteins (DPRs) are generated - poly(GR), poly(PR), poly(GA), poly(AP) and poly(GP). We developed a range of novel Drosophila models to show that the DPRs play an important role in causing C9orf72 FTD/ALS. We have now identified several novel modifiers of C9orf72 repeat toxicity in adult Drosophila neurons, and the aim of this post is to further investigate these novel modifiers in flies by using fly genetics and pharmacological treatments, and fly phenotyping, including molecular and biochemical techniques
Requirements: Applicants must have a PhD or equivalent experience in life sciences research, and experience with molecular and biochemical techniques, microscopy and imaging
   
Text: Research Fellow, - Ref:1789075 Click here to go back to search results Apply Now UCL Department / Division Institute of Neurology Specific unit / Sub department Department of Neurodegenerative Disease Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) ?35,328 - ?42,701 per annum Duties and Responsibilities Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. A GGGGCC (G4C2) repeat expansion in C9orf72 is the most frequent genetic cause.The repeats undergo an unconventional translation mechanism, termed repeat-associated non-ATG translation, whereby they mediate their own translation into proteins, without the need for an ATG start codon. Five different dipeptide repeat proteins (DPRs) are generated - poly(GR), poly(PR), poly(GA), poly(AP) and poly(GP). We developed a range of novel Drosophila models to show that the DPRs play an important role in causing C9orf72 FTD/ALS (Mizielinska et al Science 2014, 345(6201):1192-1194). We have now identified several novel modifiers of C9orf72 repeat toxicity in adult Drosophila neurons, and the aim of this post is to further investigate these novel modifiers in flies by using fly genetics and pharmacological treatments, and fly phenotyping, including molecular and biochemical techniques. The post holder will join a multidisciplinary team working on multiple aspects of C9orf72-induced neurodegeneration, including several researchers working across the laboratories of Profs Adrian Isaacs and Linda Partridge. The post is available immediately and is funded by grants from the European Research Council and the UK DRI @ UCL for three years in the first instance. Key Requirements Applicants must have a PhD or equivalent experience in life sciences research, and experience with molecular and biochemical techniques, microscopy and imaging. Strong problem-solving abilities, excellent oral and written communication skills, good inter-personal skills, and demonstrable organisational skills are also required. Further Details A Job Description and Person Specification can be accessed at the bottom of this page. To apply for the vacancy, please click on the 'Apply Now' button below. If you have any queries regarding the application process, please contact Miss E Bertram, HR Manager, UCL Institute of Neurology (email: IoN.HRAdmin@ucl.ac.uk); informal enquiries regarding the post welcome to Prof Adrian Isaacs (email: a.isaacs@ucl.ac.uk). UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 18 Feb 2019 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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