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Position: Research Fellow
Institution: University College London
Department: Institute of Ophthalmology
Location: London, United Kingdom
Duties: The appointed individual will join a collaborative team, to model disease and test antisense oligonucleotide (ASO) therapies. Primary patient-derived corneal endothelial cells will be used as an in vitro model system to probe mechanisms of disease and test the efficacy of ASO therapies targeting the CTG triplet-repeat
Requirements: The successful applicant should have a PhD in a relevant subject, excellent communication skills, and show a strong commitment to high quality research. Research experience and knowledge of genetics and cell biology is essential
   
Text: Research Fellow, - Ref:1788136 Click here to go back to search results Apply Now UCL Department / Division Institute of Ophthalmology Location of position London Grade 7 Hours Full Time Salary (inclusive of London allowance) ?35,328 - ?40,437 per annum Duties and Responsibilities There is an opportunity for a postdoctoral research fellow to work as part of a multidisciplinary team comprising scientists and clinicians to develop an antisense oligonucleotide (ASO) therapy for Fuchs endothelial corneal dystrophy (FECD). FECD is a common, age-associated corneal dystrophy that can lead to severely impaired vision. It is estimated to affect more than 4.5% of people over 50 years of age, and accounts for more than 1,000 corneal transplantations per year in the UK. Expansion (≥50 copies) of a non-coding trinucleotide repeat in TCF4 confers > 76-fold risk for FECD and has been identified in approximately 75% of affected individuals. The appointed individual will join a collaborative team, led by Dr Alice Davidson, to model disease and test antisense oligonucleotide (ASO) therapies. Primary patient-derived corneal endothelial cells will be used as an in vitro model system to probe mechanisms of disease and test the efficacy of ASO therapies targeting the CTG triplet-repeat. The position is available for 1 year in the first instance, through a research collaboration with a biotech partner, and is based at UCL Institute of Ophthalmology which is adjacent to Moorfield?s Eye Hospital. Key Requirements The successful applicant should have a PhD in a relevant subject, excellent communication skills, and show a strong commitment to high quality research. Research experience and knowledge of genetics and cell biology is essential. Previous experience in the following techniques will also be desirable, but full training will be provided, where necessary; mammalian cell culture, immunocytochemistry (ICC), fluorescent in situ hybridization (FISH), confocal microscopy and quantitative image analysis expertise, quantitative PCR, digital droplet PCR analysis and RNA-Seq data analysis. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the 'Apply Now' button below. Informal enquiries about the post may be made to Dr Alice Davidson (email: alice.davidson@ucl.ac.uk). If you have any enquiries regarding the application process please email: hr.ioo@ucl.ac.uk. UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 10 Feb 2019 Latest time for the submission of applications 23:59 Interview date TBC Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about UCL working life including the benefits we offer and UCL Terms and Conditions related to this job. Job Description and Person Specification Apply Now
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