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Position: Postdoctoral Research Fellow - Biological and Medical Sciences
Institution: Oxford Brookes University
Location: Oxford, Oxfordshire, United Kingdom
Duties: Our lab seeks a researcher to develop projects on single-cell analysis of planarian and invertebrate stem cell differentiation and regeneration. Single-cell sequencing methods are revolutionizing the study of stem cells. The flatworm Schmidtea mediterranea is a very promising model for in vivo stem cell biology thanks to its large number of stem cells that continuously differentiate to all adult cell types and that enable its amazing regenerative capacities. We have previously used single-cell transcriptomics to study stem cell differentiation in planarians. Combining clustering algorithms with graph mathematics and RNA metabolism information we were able to reconstruct the differentiation lineage tree of planarian stem cells
Requirements: The successful applicant will have a PhD or equivalent experience in genomic or transcriptomic analysis and must have good computational skills, including experience in R and Unix
   
Text: UK time and date: 09-January-2019 19:12 Applicant Options Search Current Job Vacancies Register New Account Login Terms & Conditions Help and Support Click here for help with applying and information about working at Oxford Brookes Job Details Postdoctoral Research Fellow - Biological and Medical Sciences ?31,302 rising annually to ?34,189 Full Time, Fixed Term - Researcher The Solana lab seeks a computational researcher to develop projects on single-cell analysis of planarian and invertebrate stem cell differentiation and regeneration. This position is funded by an MRC grant. Single-cell sequencing methods are revolutionizing the study of stem cells. The flatworm Schmidtea mediterranea is a very promising model for in vivo stem cell biology thanks to its large number of stem cells that continuously differentiate to all adult cell types and that enable its amazing regenerative capacities. We have previously used single-cell transcriptomics to study stem cell differentiation in planarians. Combining clustering algorithms with graph mathematics and RNA metabolism information we were able to reconstruct the differentiation lineage tree of planarian stem cells. Future projects in the lab will use these methods and develop them further to study stem cells in planarians and other organisms. Planarians offer the advantage that the whole lineage tree of differentiation is present in just one stage, their adult. Therefore, we can study all differentiated cells, their progenitors and the stem cells all at once. We will use RNAi-mediated gene knockdown in combination with single-cell analysis to profile the effects of each gene in each population at the single-cell level. This will allow elucidating the effect of several transcriptional, posttranscriptional and epigenetic regulators in stem and differentiated cells. The successful applicant will have a PhD or equivalent experience in genomic or transcriptomic analysis and must have good computational skills, including experience in R and Unix. Additionally, the applicant must have organisational and time management skills, and ability to work independently. Main duties include: Working closely with the Head of the Research Group and others on specific research project on planarian stem cell differentiation Responsibility for planning and carrying out computational work, data analysis & interpretation and report writing Assisting with the preparation of papers for publication and make presentations at meetings and/or conferences Conducting literature searches and reviews Attending conferences/workshops and present papers as required Reporting on a regular basis to the Head of the Research Group Assisting other researchers in the Research Group (e.g. students, visitors) as required Assisting with the general running of the research group Contributing to the research culture of the department Undertaking any teaching activities that may be agreed with the Head of the Research Group and in line with any Funding Body?s rules/regulations e.g. tutorials, practicals For informal enquiries please contact Dr. Jordi Solana (jsolana@brookes.ac.uk) The University has adopted equality, diversity and inclusion as core values. We welcome applications from suitably qualified candidates whatever their background, and especially from BAME candidates who are under-represented in our workforce. To email the post of Postdoctoral Research Fellow - Biological and Medical Sciences to a friend copy and paste link below: https://my.corehr.com/pls/oburecruit/erq_jobspec_details_form.jobspec?p_id=061662 Closing Date : 07-Feb-2019 Vacancy ID : 061662 Faculty or Directorate : Health and Life Sciences Location : Gipsy Lane Site, Headington Campus For more information : hrteam-recruitment@brookes.ac.uk Posted on : 03-Jan-2019 Click on the link(s) below to view documents Filesize P. All about Brookes 3333.5 A Job Description 175.5 B Person Specification 10.5 Return to Search Apply for Job
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