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Position: MRC Postdoctoral Research Scientist LMS
Institution: Medical Research Council
Location: London, United Kingdom
Duties: Original research contributions to the core program of the Computational Regulatory Genomics Group. Establish an independent research topic within the general scope of the group’s scientific interests. Contribution toward the functioning of group’s computational infrastructure and development of algorithms and software. Active participation in training of the staff and students by providing advice and information to PhD and MSc students in the group. Possible direct supervision of PhD or MSc students (max. one at a time)
Requirements: PhD (or equivalent experience) in computational biology and regulatory genomics. Strong publication record, including first-author papers, and evidence of ability to write scientific papers independently. Background in machine learning methods for analysing genome organisation. Evidence of proficiency in more than one general programming language (Python or C/C++ are preferred) and experience with programming and analysis of next generation sequencing data in R/Bioconductor. experience with computational analysis of genomic regulatory elements, gene expression or transcriptional regulatory networks. Knowledge of molecular biology and genomics. Knowledge of eukaryotic gene regulation. Experience with extraction and analysis of genome-wide data from ArrayExpress, GEO, Ensembl and/or UCSC Genome Browser. High level of motivation and drive, and the desire to become an independent investigator. Evidence of ability to organise and conduct complex research projects. Good written and verbal communication skills in English. Ability to work effectively with researchers from different fields (computer scientists to experimental biologists) ranging from postgraduate students to professorial level. Ability to work both independently and as part of a team. Ability and eagerness to learn new concepts and acquire new skills in biology and computing quickly, and to seek novel and creative solutions to scientific problems. Willingness to share knowledge and skills with other members of the group on a daily basis
   
Text: MRC Postdoctoral Research Scientist LMS - 976 Open Date 23/11/2018, 11:00 Close Date 24/12/2018, 23:55 Research Institute MRC London Institute of Medical Science Research Institute / Unit Information London Instittute of Medical Sciences is an institute funded by MRC and is a division of the Faculty of Medicine at Imperial College London. Based on the Hammersmith Hospital Campus in West London, the LMS has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College. For more information, visit www.lms.mrc.ac.uk . UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org Band MRC - 4 Location London Salary £35,340 - £38,181 pa inclusive of allowances* Contract Type Fixed Term Job Type Science Full Time / Part Time Full Time Contract Length 3 years Job Description Overall purpose: The Computational Regulatory Genomics Group studies gene regulation at the genome-wide level using methods of computational genomics and epigenomics. The group is now also applying experimental techniques and developed the first low-input cap analysis of gene expression methodology to allow mapping promoters and enhancers from as little as 1000 cells. The interests of the group range from investigating sequence signals and chromatin organisation at core promoter regions to revealing rules of communication between core promoter and distal regulatory elements and how they give rise to elaborate spatio-temporal expression patterns in development. The group has a track record of excellence and innovation in computational genomics and is applying and developing experimental techniques , with numerous publications in top-tier journals and extensive international collaboration. For more information, visit https://lms.mrc.ac.uk/research-group/computational-regulatory-genomics/ . We are looking for a skilled and ambitious postdoctoral researcher with a background in comparative genomics, promoter analysis, experimental functional genomics or a related field. The candidates should have a strong publication record indicating potential for independent high-impact research, as well as in-depth knowledge of molecular biology and evidence of knowledge in programming (including R/Bioconductor) and analysis of genomics data. The post holder will investigate the mechanism, sequence and epigenetic signatures of long-range developmental regulation, promoter function and enhancer:promoter communication, using state-of-the-art existing methods of computational and /or experimental genomics and developing new innovative approaches. He/she will work with the network of collaborators of Lenhard group and be expected to establish an independent research topic within the general scope of the group’s scientific interests. Main duties / key responsibilities: Original research contributions to the core program of the Computational Regulatory Genomics Group Establish an independent research topic within the general scope of the group’s scientific interests Contribution toward the functioning of group’s computational infrastructure and development of algorithms and software Active participation in training of the staff and students by providing advice and information to PhD and MSc students in the group Possible direct supervision of PhD or MSc students (max. one at a time) The appointee will: 1) Conduct research as part of the group’s core program 2) Develop and independently conduct their own research topic within the group’s core program 3) Analyse, manage, communicate and publish data and software tools 4) Take an active part in the academic activities of the Computational Regulatory Genomics group including group meetings, group journal clubs, training and organisational aspects 5) Take an active part in the academic activities of the LMS, including journal clubs and seminar presentations 6) Present original results at national and international scientific meetings This is an MRC Postdoctoral Research Scientist position to support post-doctoral scientists in early or changed career training and help establish them as successful research scientists in their chosen field. We offer a highly attractive benefits package including competitive salary and pension scheme. Working relationships: The post-holder will report directly to the head of the group, Professor Boris Lenhard. Person Specification Education / Qualifications / Training required (will be assessed from application form): Essential: PhD (or equivalent experience) in computational biology and regulatory genomics Previous work experience required (will be assessed from application and at interview): Essential: Strong publication record, including first-author papers, and evidence of ability to write scientific papers independently Background in machine learning methods for analysing genome organisation Evidence of proficiency in more than one general programming language (Python or C/C++ are preferred) and experience with programming and analysis of next generation sequencing data in R/Bioconductor experience with computational analysis of genomic regulatory elements, gene expression or transcriptional regulatory networks Knowledge and experience (will be assessed from application form and at interview): Essential: Knowledge of molecular biology and genomics Knowledge of eukaryotic gene regulation Experience with extraction and analysis of genome-wide data from ArrayExpress, GEO, Ensembl and/or UCSC Genome Browser Desirable: Knowledge of applications of statistics in molecular biology, genomics or population genetics Applications of machine learning, Bayesian data analysis and linear algebra in computational biology Personal skills/behaviours/qualities (will be assessed at interview): Essential: High level of motivation and drive, and the desire to become an independent investigator Evidence of ability to organise and conduct complex research projects Good written and verbal communication skills in English Ability to work effectively with researchers from different fields (computer scientists to experimental biologists) ranging from postgraduate students to professorial level Ability to work both independently and as part of a team Ability and eagerness to learn new concepts and acquire new skills in biology and computing quickly, and to seek novel and creative solutions to scientific problems Willingness to share knowledge and skills with other members of the group on a daily basis. Further Information Please upload your CV and research statement not longer than two pages, submitted as a separate document. The research statement should outline your most important achievements to date and a brief vision of your present research interests and future career. *Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year. The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council. Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future. Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy. UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs. We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.
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