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Position: Postdoc in Computational Genomics for Genomics of Antibiotics Producers
Institution: Technical University of Denmark
Department: Center for Biosustainability (CFB)
Location: Kongens Lyngby, Lyngby‐Taarbæk Municipality, Denmark
Duties: Coordinating the genome-sequencing of interesting actinomycete producer strains at commercial sequencing providers and the internal DTU Biosustain NGS sequencing lab; the task includes genome (hybrid) assembly and the annotation of sequence data. Genome mining for secondary metabolite biosynthetic gene clusters. Support the experimental scientists in prioritizing the identified biosynthetic gene clusters. Comparative Genomics analyses of the sequenced strains; including development of user-friendly tools. Development of automated software pipelines for experimental design based on the genome mining results
Requirements: Candidates should have a PhD degree in bioinformatics, microbiology, biotechnology or equivalent field. For carrying out the project, we expect you to have: excellent knowledge of the research field documented by experience in computational biology/analysis of bacterial genomic data. excellent skills and documented experience in handling and processing larger scale next-generation sequencing (NGS) data, comparative genomics methods, programming experience (preferably Python, R) and computational tools to analyse and visualise such data are essential. Furthermore, knowledge and previous experience in microbial natural products biosynthesis, actinomycete biology or genetic/metabolic engineering and general lab-experience are highly advantageous
   
Text: Postdoc in Computational Genomics for Genomics of Antibiotics Producers Center for Biosustainability Del til Facebook Del til Twitter Del til LinkedIn Tuesday 27 Nov 18 Apply for this job Apply no later than 1 January 2019 Apply for the job at Center for Biosustainability by completing the following form. Apply online The New Bioactive Compound section of DTU Biosustain is dedicated to finding the next generation of antimicrobial lead compounds by integrating innovative screening approaches, computational biology and metabolic engineering. Within the Novo Nordisk Foundation funded Challenge Grant project “Integration of Informatics and Metabolic Engineering for the discovery of Novel Antibiotics (IIMENA) we are currently setting up a streamline pipeline in collaboration with international partner institutions from Spain and South Korea. Within the IIMENA project, we will identify a huge number of actinomycetes producing bioactive compounds against our panel of clinical test organisms. Many of these strains will be sequenced and subjected to genome mining for the biosynthetic gene clusters encoding the production of the bioactive compounds. In order to reach this ambitious goal, we are searching for an excellent postdoctoral scientist to develop and implement computational tools and workflows to rapidly identify and characterize biosynthetic pathways for secondary metabolites and their bioactivities as a basis for further engineering of the biosynthetic pathways. Responsibilities and tasks Within the project, you will be responsible for Coordinating the genome-sequencing of interesting actinomycete producer strains at commercial sequencing providers and the internal DTU Biosustain NGS sequencing lab; the task includes genome (hybrid) assembly and the annotation of sequence data. Genome mining for secondary metabolite biosynthetic gene clusters Support the experimental scientists in prioritizing the identified biosynthetic gene clusters Comparative Genomics analyses of the sequenced strains; including development of user-friendly tools. Development of automated software pipelines for experimental design based on the genome mining results The position is fully integrated into the interdisciplinary NBC research team consisting of Chemists, Microbiologists and Computational Biologists. You will work in close collaboration with the other iimena project scientists, members of the NBC section, colleagues at DTU Biosustain and other DTU departments/centers, such as the Center for Microbial Secondary Metabolits (CeMiSt). Qualifications Candidates should have a PhD degree in bioinformatics, microbiology, biotechnology or equivalent field. For carrying out the project, we expect you to have excellent knowledge of the research field documented by experience in computational biology / analysis of bacterial genomic data. excellent skills and documented experience in handling and processing larger scale next-generation sequencing (NGS) data, comparative genomics methods, programming experience (preferably Python, R) and computational tools to analyse and visualise such data are essential. Furthermore, knowledge and previous experience in microbial natural products biosynthesis, actinomycete biology or genetic / metabolic engineering and general lab-experience are highly advantageous. As our future co-worker, you enjoy working on complex topics and bring strong ambition, and work ethics and attention to detail communication and team-playing skills, but also the ability to work independently towards applied research goals in a multi-disciplinary international team of scientists. Our team language is English, therefore excellent English skills for working in a highly international research environment are required. We offer DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. Salary and terms of employment The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. Workplace and period of employment: Workplace is The Novo Nordisk Foundation Center for Biosustainability at DTU main campus in Kgs. Lyngby. The period of employment is 2 years; the position is available immediately Further information Further information may be obtained from Prof. Dr. Tilmann Weber (IIMENA coordinator) by email tiwe@biosustain.dtu.dk You can read more about DTU Biosustain on www.biosustain.dtu.dk and the iimena project at http://www.iimena.org Application procedure Please submit your online application no later than 1 January 2019 (local time) . To apply, please open the link "Apply online", fill out the online application form. The following must be attached in English : Application (cover letter) CV Diploma (MSc/PhD) List of publications Applications and enclosures received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. DTU Biosustain is an international research center of excellence developing next generation cell factories and bioprocesses for sustainable production of high-value chemical compounds as well as protein-based products. The center uses advanced metabolic engineering techniques and computational biology ensuring efficient and cost-effective design and construction processes. The center’s activities are a balanced mix of basic and translational research, complemented by an emphasis on business development to facilitate commercialization of new cell factories and associated technologies. DTU Biosustain offers state-of-the-art research facilities and assembles world leaders in the field thus offering a unique platform providing excellent talent development and career opportunities. DTU is a technical university providing internationally leading research, education, innovation and scientific advice . Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.
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