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Position: Postdoctoral Research Associate - Synthetic Approaches to Study Gene Regulation
Institution: University of Oxford
Department: Biochemistry
Location: Oxford, Oxfordshire, United Kingdom
Duties: We are seeking to appoint a Postdoctoral Research Associate to study how CpG islands use chromatin-based and epigenetic mechanisms to regulate gene expression. The candidate will study these fundamental processes using cutting edge synthetic and quantitative approaches. This will rely on the use of rationally engineered gene regulatory elements, their insertion into cells using CRISPR/Cas9-based genome engineering, and single cell approaches to study gene expression. Through these studies we aim to define how CpG islands and chromatin states at gene promoters function to control gene expression in normal biology and human disease
Requirements: PhD/DPhil, or be near completion of a PhD/DPhil, in a relevant subject area, strong background in (or the desire to learn) synthetic approaches to dissect the molecular processes that underpin gene expression. The ability to work both independently and as part of a team in order to make new discoveries and drive the research to publication is essential. You will have a keen interest in chromatin biology, epigenetics and transcription
   
Text: Postdoctoral Research Associate in Synthetic Approaches to Study Gene Regulation Department of Biochemistry, South Parks Road, Oxford Grade 7: £32,236 - £39,609 p.a. We are seeking to appoint a Postdoctoral Research Associate to join Professor Rob Kloses research group (www.kloselab.co.uk) to study how CpG islands use chromatin-based and epigenetic mechanisms to regulate gene expression. The candidate will study these fundamental processes using cutting edge synthetic and quantitative approaches. This will rely on the use of rationally engineered gene regulatory elements, their insertion into cells using CRISPR/Cas9-based genome engineering, and single cell approaches to study gene expression. Through these studies we aim to define how CpG islands and chromatin states at gene promoters function to control gene expression in normal biology and human disease. Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil, in a relevant subject area. You will have a strong background in (or the desire to learn) synthetic approaches to dissect the molecular processes that underpin gene expression. The ability to work both independently and as part of a team in order to make new discoveries and drive the research to publication is essential. You will have exceptional organisation, communication and multitasking skills and have a keen interest in chromatin biology, epigenetics and transcription. Ideally you will have experience in: mammalian cell culture, design of synthetic gene regulatory DNA sequences, genome engineering, and single-cell methods to study gene expression, although training in some of these areas will be available. This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. Further particulars, including details of how to apply, can be obtained from the document below. The closing date for applications is 12.00 noon on Friday 9 November 2018, with interviews for shortlisted candidates to be held as soon as possible thereafter. Contact Person : HR Officer Vacancy ID : 137464 Contact Phone : 01865 613204 Closing Date : 09-Nov-2018 Contact Email : jobs@bioch.ox.ac.uk Click on the link(s) below to view documents Filesize 137464 Research Associate Gr 7 JD - Klose 573
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