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Position: Postdoctoral Research Scientist
Institution: Medical Research Council
Department: Institute of Medical Science
Location: London, United Kingdom
Duties: To think independently, design experiments and conduct high-quality research in line with the agreed project aims. To critically analyse and present data, ensuring reliability, reproducibility and statistical robustness. To keep abreast of current published research and preprints, and integrate findings into own project ideas and techniques. To develop new techniques and protocols as necessary for the project. To attend all lab and related research meetings, and to present work when required. To interact and collaborate with researchers in related projects, and take an active role in the academic life of the MRC LMS
Requirements: PhD degree or equivalent in a relevant biochemical/biological/biomedical discipline (or be in the final stages of completing one). Strong academic track record. Significant experience in mammalian biological systems (e.g., tissue culture, mouse models). Extensive practical experience in molecular biology and biochemistry techniques (e.g. ChIP, qRT-PCR, western blotting, cloning)
   
Text: MRC Postdoctoral Research Scientist - LMS 882 Open Date 31/07/2018, 09:00 Close Date 02/09/2018, 23:55 Research Institute MRC London Institute of Medical Science Research Institute / Unit Information The LMS is a leading MRC-funded Institute affiliated with Imperial College London, and based on the Hammersmith Hospital Campus in West London. The LMS provides investigators from clinical and basic science backgrounds with a thriving research environment, state-of-the-art facilities, and the opportunity to pursue innovative, multi-disciplinary projects. For more information, visit: http://www.lms.mrc.ac.uk UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org Band MRC - 4 Location London Salary £35,340 - £38,181 pa inclusive* Contract Type Fixed Term Job Type Science Full Time / Part Time Full Time Contract Length 3 years Job Description Overall purpose: The Chromatin & Development group , led by Dr Michelle Percharde, is focused on understanding the molecular events surrounding cell fate choices during early development. We aim to dissect novel transcriptional, epigenetic, and signalling axes important for embryogenesis. Recent research indicates that Transposable Elements (TEs) may have important, undiscovered roles during development, and we are particularly interested in uncovering how Transposable Element (TE) regulation is important during embryogenesis, and how unrestrained TE expression may contribute to disease. To answer these questions, we routinely use mouse embryonic stem cells (ESCs) and mouse embryos as models, adopting a combination of genome-wide techniques, CRISPR/Cas9 technology, high-resolution microscopy, biochemistry and molecular embryology approaches to probe gene and TE function during development. Please see www.perchardelab.com for more information. We seek a highly motivated and talented postdoctoral scientist to join the group. The post-holder will be a key member of the Chromatin & Development group, and as such will enjoy a high level of scientific responsibility. They should have a strong background in chromatin, gene regulation and/or early development, and will be expected to be proactive in developing their research question within the group’s areas of interest and expertise. Main Responsibilities: To think independently, design experiments and conduct high-quality research in line with the agreed project aims To critically analyse and present data, ensuring reliability, reproducibility and statistical robustness. To keep abreast of current published research and preprints, and integrate findings into own project ideas and techniques To develop new techniques and protocols as necessary for the project To attend all lab and related research meetings, and to present work when required To interact and collaborate with researchers in related projects, and take an active role in the academic life of the MRC LMS To assist others and co-supervise students when required To attend and contribute to journal clubs and seminar presentations To present data at national and international meetings (where and when appropriate) To write-up work for publication in peer-reviewed journals, and assist with data and writing of grant proposals, when necessary To form good working relationships with other members of the group, as well as internal and external collaborators To contribute to the development and maintenance of the group’s experimental infrastructure as appropriate. To help with the daily running of the lab by assisting with general lab duties as required This is an MRC Postdoctoral Scientist position, which provides training and development to support postdoctoral scientists in early or changed career paths, helping to establish them as a successful research scientist in their chosen field. The position is for 3 years and available immediately. Person Specification Education / Qualifications / Training required (will be assessed from application form): Essential: PhD degree or equivalent in a relevant biochemical/biological/biomedical discipline (or be in the final stages of completing one). Strong academic track record Previous work experience required (will be assessed from application form and at interview): Essential: Significant experience in mammalian biological systems (e.g., tissue culture, mouse models) Extensive practical experience in molecular biology and biochemistry techniques (e.g. ChIP, qRT-PCR, western blotting, cloning) Desirable: Extensive experience in working with mouse and/or human embryonic stem cell culture Use of the mouse (mus musculus) as a model system (e.g. breeding, colony maintenance, procedures), particularly mouse embryo manipulation Prior experience with CRISPR/Cas9 techniques and gene-editing strategies Previous experience with genome-wide experiments and/or analysis (RNA-seq, ChIP-seq, ATAC-seq) Experience working with RNA and/or transposable elements Knowledge and experience (will be assessed from application form and at interview): Essential: Proven publication record, with one or more first-author publications in a peer-reviewed international journal (being submitted or published by time of interview) Strong conceptual background in at least one of the following: mammalian epigenetics, development, gene regulation and transposable element biology Excellent communication skills in English, both verbal (i.e. seminar presentations, participation at lab meetings, discussions with the PI) and written (i.e. reports, preparation of manuscripts) Established understanding of basic statistics, scientific reliability, and the generation of reproducible data, including being able to critically assess own and others’ results Desirable: Experience in image analysis, basic bioinformatics, and CRISPR/Cas9 or gene editing technologies Past experience in student supervision Previous experience in presenting scientific data at national or international scientific conferences Personal skills/behaviours/qualities (will be assessed at interview): Essential: Ability to work as an enthusiastic part of a team. Ability to conduct research independently, including experiment conception, design, execution, analysis and presentation to the group. Experience in learning and acquisition of new skills, technique troubleshooting, and ability to seek creative solutions to scientific problems. Willingness to work flexible hours as the project demands, and to travel nationally or internationally for research or conference attendance Enthusiasm to work collaboratively and share skills and knowledge with other team members. Ability to produce high-quality data, assess experimental reliability, and conduct all experiments with high scientific rigor and reproducibility. Further Information Additional information: Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities. Please upload your CV, the names and contacts of two scientific references, along with a cover letter stating why you are applying for this post (showing evidence against the requirements as per the Job Description and Person Specification). Please quote reference number LMS-882. * Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year. The MRC is a great place to work and progress your career, be it in scientific research or the support functions. The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council. Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future. Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy. Final appointments will be subject to pre-employment screening.
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