Visit All-Acad.com with more than 100,000 Jobs for Academics!
                    
Position: Senior Research Associate
Institution: University College London
Department: Institute of Prion Diseases
Location: London, United Kingdom
Duties: We are seeking to recruit to a Senior Research Associate position at UCL Grade 8. Following an initial training period you will undertake research to investigate the composition and three dimensional structures of infectious prion strains. The existence of prion strains constitutes protein-based inheritance and the structural basis of this is of wide biological and evolutionary interest. Work will principally involve: imaging of purified prions by negative strain and cryo-electron microscopy; biochemical purification of prions from mouse brain; and, preparation of purified prion preparations suitable for analyses by mass spectroscopy and other analytical techniques
Requirements: A background in negative stain and cryo-electron microscopy and protein structural biology is highly desirable. Excellent verbal and written communication skills are required to communicate research findings in peer reviewed journals and scientific presentations. Experience of working in microbiological containment level 3 facilities would be an advantage. The post-holder will work closely with existing staff at UCL and Birkbeck College but must have the ability to work independently
   
Text: Senior Research Associate , - Ref:1736779 Click here to go back to search results Apply Now UCL Department / Division Institute of Prion Diseases Location of position London Grade 8 Hours Full Time Salary (inclusive of London allowance) ?43,023 to ?50,753 per annum Duties and Responsibilities We are one of the world?s leading research centres for the study of prions and their wider relevance to neurodegenerative disease notably in Alzheimer?s disease ( www.prion.ucl.ac.uk ). The Institute is highly multidisciplinary with close integration of structural and molecular biology, genetics, cellular and animal models, small molecule and immuno-therapeutics and clinical research. MRC and UCL have jointly invested ?30 million in provision of a dedicated new building in central London for the Institute supporting the vision to expand research in protein misfolding and aggregation in neurodegenerative disease. We are seeking to recruit to a Senior Research Associate position at UCL Grade 8. Following an initial training period you will undertake research to investigate the composition and three dimensional structures of infectious prion strains. The existence of prion strains constitutes protein-based inheritance and the structural basis of this is of wide biological and evolutionary interest. In addition understanding how certain assemblies of misfolded proteins can act like pathogens spreading throughout the brain is a major research focus in neurodegeneration. EM work is in collaboration with Professor Helen Saibil FRS at Birkbeck College London, an internationally renowned expert in electron microscopy of protein assemblies and access to EM facilities at Birkbeck will be provided as well as full time access to a dedicated EM at the Prion Unit. Work will principally involve: imaging of purified prions by negative strain and cryo-electron microscopy; biochemical purification of prions from mouse brain; and, preparation of purified prion preparations suitable for analyses by mass spectroscopy and other analytical techniques. The post is available from 1st September 2018 and funded to 31 March 2022 in the first instance. Key Requirements A background in negative stain and cryo-electron microscopy and protein structural biology is highly desirable. Excellent verbal and written communication skills are required to communicate research findings in peer reviewed journals and scientific presentations. Experience of working in microbiological containment level 3 facilities would be an advantage. The post-holder will work closely with existing staff at UCL and Birkbeck College but must have the ability to work independently. Further Details A job description and person specification can be accessed at the bottom of this page. To apply for the vacancy please click on the ?Apply Now? button below. If you have any queries regarding the vacancy and/or application process, please contact Dr Jonathan Wadsworth: j.wadsworth@prion.ucl.ac.uk UCL Taking Action for Equality We will consider applications to work on a part-time, flexible and job share basis wherever possible. Closing Date 31 Aug 2018 Latest time for the submission of applications 23:59 Interview date TBC Our department is working towards an Athena SWAN award. We are committed to advancing gender equality within our department. This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff. Please use these links to find out more about the UCL Terms and Conditions related to this job, employee benefits that we offer and further information about UCL . Senior Research Associate (JW) Apply Now
Please click here, if the Job didn't load correctly.







Please wait. You are being redirected to the Job in 3 seconds.