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Position: Postdoc - Computational Biophysics
Institution: Université de Lausanne
Department: Pharmacology and Toxicology
Location: Lausanne, Switzerland
Duties: This laboratory works experimentally with a class of ion channels, the acid-sensing ion channels (ASICs), with the aim of understanding their molecular mechanisms of function. ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia. Crystal structures of some of the ASIC conformations are available. We are looking for a talented and motivated postdoctoral researcher.The postdoctoral fellow will carry out molecular dynamics simulations and apply other computational approaches in order to guide the experimental work and to interpret its findings
Requirements: Applicants should hold a doctorate in computational biophysics or a related domain and have extensive experience with molecular dynamics simulations applied to the understanding of protein structure-function relationship. Ideally the candidate should have worked on ion channels or other complex membrane proteins. You will work with a team of experimental researchers, and you are expected to work independently and to be able to develop computational strategies in order to provide answers for questions arising from experimental observations as well as to guide future experimental work
   
Text: Introduction The University of Lausanne is a higher teaching and research institution composed of seven faculties where approximately 14,300 students and nearly 3,900 collaborarators, professors, and researchers work and study. Ideally situated near Lausanne's city center, the University brings together over 120 nationalities. Presentation A postdoctoral position is available in the laboratory of Stephan Kellenberger at the Department of Pharmacology and Toxicology (DPT) of the University of Lausanne.This laboratory works experimentally with a class of ion channels, the acid-sensing ion channels (ASICs), with the aim of understanding their molecular mechanisms of function. ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Kellenberger and Schild, Pharmacol Rev 67: 1-35, 2015). Crystal structures of some of the ASIC conformations are available. Job information Expected start date in position : Fall 2017 Contract length : 2 years, with an initial renewable contract of 1 year Activity rate : 100% Workplace : Department of Pharmacology, Lausanne Your responsibilities We are looking for a talented and motivated postdoctoral researcher.The postdoctoral fellow will carry out molecular dynamics simulations and apply other computational approaches in order to guide the experimental work and to interpret its findings. Your qualifications Applicants should hold a doctorate in computational biophysics or a related domain and have extensive experience with molecular dynamics simulations applied to the understanding of protein structure-function relationship. Ideally the candidate should have worked on ion channels or other complex membrane proteins. You will work with a team of experimental researchers, and you are expected to work independently and to be able to develop computational strategies in order to provide answers for questions arising from experimental observations as well as to guide future experimental work. What the position offers you We are a small, motivated team investigating ion channel function. We will provide you experimental results that you can use as a basis for your approaches, and we look forward to a close mutual interaction that will advance our understanding of the molecular mechanisms of ASIC function. The position is for 2 years, with an initial, renewable contract of 1 year. The DPT, with 10 research teams, offers a stimulating and competitive research environment in modern biology with multidisciplinary expertise ( www.unil.ch/dpt). Lausanne, with its university and the EPFL is a center of life science research. Contact for further information Dr. Stephan Kellenberger PD-MER University of Lausanne Department of Pharmacology and Toxicology Rue du Bugnon 27 1011 Lausanne https://www.unil.ch/dpt/home/menuinst/recherche/groupe-kellenberger.html Your application Deadline: July 28 2017 Applications are invited in the form of a motivation letter, a curriculum vitae, a brief description of research experience and doctoral thesis, and the names and addresses of three academic references. Please send your full application in word or PDF format. Only applications through this website will be taken into account. We thank you for your understanding. Additional information For further information, please consult the following publications that illustrate our approaches: Roy S et al. (2013) FASEB J 27: 5034-45 Vullo S et al. (2017) Proc Natl Acad Sci U S A 114: 3768-73 Seeking to promote an equitable representation of men and women among its staff, the University encourages applications from women. Apply Apply Using LinkedIn™ Save Job Email Job to Friend Return to List
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